Inhibition of tissue-factor-mediated thrombin generation by simvastatin

D Ferro, S Basili, C Alessandri, D Cara, F Violi - Atherosclerosis, 2000 - Elsevier
A previous study has shown that simvastatin reduces in vivo clotting activation and
monocyte tissue factor (TF) expression. This effect, however, was only in part attributable to
the reduction of serum cholesterol, suggesting that more than one mechanism may be
involved. Furthermore, it was not investigated if the inhibition of clotting activation was
dependent upon the reduced expression of monocyte TF. In order to assess if simvastatin
directly affects clotting activation, we developed an in vitro method in which clotting system is …