8, 5′-Cyclopurine-2′-deoxynucleosides in DNA: mechanisms of formation, measurement, repair and biological effects
P Jaruga, M Dizdaroglu - DNA repair, 2008 - Elsevier
8, 5′-Cyclo-2′-deoxyadenosine (cdA) and 8, 5′-cyclo-2′-deoxyguanosine (cdG) are
among the major lesions formed in DNA by hydroxyl radical attack on 2′-deoxyadenosine
and 2′-deoxyguanosine, respectively, followed by intramolecular cyclization between C5′
and C8. Mechanisms of formation of these unique tandem lesions were elucidated. The 8,
5′-cyclization causes an unusual puckering of the sugar moiety giving rise to significant
distortion in the DNA double helix. Methodologies were developed for the measurement of …
among the major lesions formed in DNA by hydroxyl radical attack on 2′-deoxyadenosine
and 2′-deoxyguanosine, respectively, followed by intramolecular cyclization between C5′
and C8. Mechanisms of formation of these unique tandem lesions were elucidated. The 8,
5′-cyclization causes an unusual puckering of the sugar moiety giving rise to significant
distortion in the DNA double helix. Methodologies were developed for the measurement of …