Rational design of compounds to mimic the functional domains of BCL‐2 family proteins
requires chemical reproduction of the biologic complexity afforded by the relatively large and
folded surfaces of BCL‐2 homology (BH) domain peptide α‐helices. Because the
intermolecular handshakes of BCL‐2 proteins are so critical to controlling cellular fate, we
undertook the development of a toolbox of peptidic ligands that harness the natural potency
and specificity of BH α‐helices to interrogate and potentially medicate the deregulated …