Invasive pneumococcal disease caused by nonvaccine serotypes among Alaska native children with high levels of 7-valent pneumococcal conjugate vaccine …
RJ Singleton, TW Hennessy, LR Bulkow, LL Hammitt… - Jama, 2007 - jamanetwork.com
ContextWith routine childhood vaccination using heptavalent pneumococcal conjugate
vaccine, one concern has been the potential for emergence and expansion of replacement
disease caused by serotypes not contained in the heptavalent conjugate vaccine.
ObjectiveTo determine whether replacement disease is associated with the overall decline
in invasive pneumococcal disease among Alaska Native children. Design, Setting, and
PatientsAlaska statewide longitudinal population-based laboratory surveillance of invasive …
vaccine, one concern has been the potential for emergence and expansion of replacement
disease caused by serotypes not contained in the heptavalent conjugate vaccine.
ObjectiveTo determine whether replacement disease is associated with the overall decline
in invasive pneumococcal disease among Alaska Native children. Design, Setting, and
PatientsAlaska statewide longitudinal population-based laboratory surveillance of invasive …