[PDF][PDF] A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

RM Neve, K Chin, J Fridlyand, J Yeh, FL Baehner… - Cancer cell, 2006 - cell.com
RM Neve, K Chin, J Fridlyand, J Yeh, FL Baehner, T Fevr, L Clark, N Bayani, JP Coppe…
Cancer cell, 2006cell.com
Recent studies suggest that thousands of genes may contribute to breast cancer
pathophysiologies when deregulated by genomic or epigenomic events. Here, we describe
a model" system" to appraise the functional contributions of these genes to breast cancer
subsets. In general, the recurrent genomic and transcriptional characteristics of 51 breast
cancer cell lines mirror those of 145 primary breast tumors, although some significant
differences are documented. The cell lines that comprise the system also exhibit the …
Summary
Recent studies suggest that thousands of genes may contribute to breast cancer pathophysiologies when deregulated by genomic or epigenomic events. Here, we describe a model "system" to appraise the functional contributions of these genes to breast cancer subsets. In general, the recurrent genomic and transcriptional characteristics of 51 breast cancer cell lines mirror those of 145 primary breast tumors, although some significant differences are documented. The cell lines that comprise the system also exhibit the substantial genomic, transcriptional, and biological heterogeneity found in primary tumors. We show, using Trastuzumab (Herceptin) monotherapy as an example, that the system can be used to identify molecular features that predict or indicate response to targeted therapies or other physiological perturbations.
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