Endothelial dysfunction enhances vasoconstriction due to scavenging of nitric oxide by a hemoglobin-based oxygen carrier
B Yu, M Shahid, EM Egorina… - The Journal of the …, 2010 - pubs.asahq.org
Background To date, there is no safe and effective hemoglobin-based oxygen carrier
(HBOC) to substitute for erythrocyte transfusion. It is uncertain whether a deficiency of
endothelial nitric oxide bioavailability (endothelial dysfunction) prevents or augments HBOC-
induced vasoconstriction. Methods Hemodynamic effects of infusion of PolyHeme (1.08 g
hemoglobin/kg; Northfield Laboratories, Evanston, IL) or murine tetrameric hemoglobin (0.48
g hemoglobin/kg) were determined in awake healthy lambs, awake mice, and anesthetized …
(HBOC) to substitute for erythrocyte transfusion. It is uncertain whether a deficiency of
endothelial nitric oxide bioavailability (endothelial dysfunction) prevents or augments HBOC-
induced vasoconstriction. Methods Hemodynamic effects of infusion of PolyHeme (1.08 g
hemoglobin/kg; Northfield Laboratories, Evanston, IL) or murine tetrameric hemoglobin (0.48
g hemoglobin/kg) were determined in awake healthy lambs, awake mice, and anesthetized …