[HTML][HTML] Recombinant adenoviral microRNA-206 induces myogenesis in C2C12 cells
W Zhang, T Wang, Y Su, W Li, LT Frame… - Medical Science Monitor …, 2011 - ncbi.nlm.nih.gov
W Zhang, T Wang, Y Su, W Li, LT Frame, G Ai
Medical Science Monitor: International Medical Journal of Experimental …, 2011•ncbi.nlm.nih.govBackground The expression of microRNA-206 (miR-206) is high in skeletal muscle but low
in most other tissues. The expression of miR-206 is increased in muscular dystrophy,
suggesting its involvement in the pathogenesis of muscle diseases. To determine the role of
miR-206 in muscle cell differentiation and explore a possible gene therapy vector, we
constructed a miR-206 adenoviral expression vector (AdvmiR-206) and tested for
transfection into C2C12 stem cells.
in most other tissues. The expression of miR-206 is increased in muscular dystrophy,
suggesting its involvement in the pathogenesis of muscle diseases. To determine the role of
miR-206 in muscle cell differentiation and explore a possible gene therapy vector, we
constructed a miR-206 adenoviral expression vector (AdvmiR-206) and tested for
transfection into C2C12 stem cells.
Summary
Background
The expression of microRNA-206 (miR-206) is high in skeletal muscle but low in most other tissues. The expression of miR-206 is increased in muscular dystrophy, suggesting its involvement in the pathogenesis of muscle diseases. To determine the role of miR-206 in muscle cell differentiation and explore a possible gene therapy vector, we constructed a miR-206 adenoviral expression vector (AdvmiR-206) and tested for transfection into C2C12 stem cells.
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