[HTML][HTML] Close functional coupling between Ca2+ release-activated Ca2+ channels, arachidonic acid release, and leukotriene C4 secretion
WC Chang, AB Parekh - Journal of Biological Chemistry, 2004 - ASBMB
In non-excitable cells, one major route for Ca 2+ influx is through store-operated Ca 2+
channels in the plasma membrane. These channels are activated by the emptying of
intracellular Ca 2+ stores, and in some cell types, particularly of hemopoietic origin, store-
operated influx occurs through Ca 2+ release-activated Ca 2+(CRAC) channels. However,
little is known about the downstream consequences of CRAC channel activation. Here, we
report that Ca 2+ entry through CRAC channels stimulates arachidonic acid production …
channels in the plasma membrane. These channels are activated by the emptying of
intracellular Ca 2+ stores, and in some cell types, particularly of hemopoietic origin, store-
operated influx occurs through Ca 2+ release-activated Ca 2+(CRAC) channels. However,
little is known about the downstream consequences of CRAC channel activation. Here, we
report that Ca 2+ entry through CRAC channels stimulates arachidonic acid production …