[HTML][HTML] Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activation
STIM1 and Orai1 are essential components of Ca 2+ release-activated Ca 2+ channels
(CRACs). After endoplasmic reticulum Ca 2+ store depletion, STIM1 in the endoplasmic
reticulum aggregates and migrates toward the cell periphery to co-localize with Orai1 on the
opposing plasma membrane. Little is known about the roles of different domains of STIM1
and Orai1 in protein clustering, migration, interaction, and, ultimately, opening CRAC
channels. Here we demonstrate that the coiled-coil domain in the C terminus of STIM1 is …
(CRACs). After endoplasmic reticulum Ca 2+ store depletion, STIM1 in the endoplasmic
reticulum aggregates and migrates toward the cell periphery to co-localize with Orai1 on the
opposing plasma membrane. Little is known about the roles of different domains of STIM1
and Orai1 in protein clustering, migration, interaction, and, ultimately, opening CRAC
channels. Here we demonstrate that the coiled-coil domain in the C terminus of STIM1 is …