[HTML][HTML] 14-3-3: Shc scaffolds integrate phosphoserine and phosphotyrosine signaling to regulate phosphatidylinositol 3-kinase activation and cell survival
Integrated cascades of protein tyrosine and serine/threonine phosphorylation play essential
roles in transducing signals in response to growth factors and cytokines. How adaptor or
scaffold proteins assemble signaling complexes through both phosphotyrosine and
phosphoserine/threonine residues to regulate specific signaling pathways and biological
responses is unclear. We show in multiple cell types that endogenous 14-3-3ζ is
phosphorylated on Tyr 179 in response to granulocyte macrophage colony-stimulating …
roles in transducing signals in response to growth factors and cytokines. How adaptor or
scaffold proteins assemble signaling complexes through both phosphotyrosine and
phosphoserine/threonine residues to regulate specific signaling pathways and biological
responses is unclear. We show in multiple cell types that endogenous 14-3-3ζ is
phosphorylated on Tyr 179 in response to granulocyte macrophage colony-stimulating …