The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development

DK Morrison - Trends in cell biology, 2009 - cell.com
DK Morrison
Trends in cell biology, 2009cell.com
The highly conserved 14-3-3 protein family has risen to a position of importance in cell
biology owing to its involvement in vital cellular processes, such as metabolism, protein
trafficking, signal transduction, apoptosis and cell-cycle regulation. The 14-3-3 proteins are
phospho-serine/phospho-threonine binding proteins that interact with a diverse array of
binding partners. Because many 14-3-3 interactions are phosphorylation-dependent, 14-3-3
has been tightly integrated into the core phospho-regulatory pathways that are crucial for …
The highly conserved 14-3-3 protein family has risen to a position of importance in cell biology owing to its involvement in vital cellular processes, such as metabolism, protein trafficking, signal transduction, apoptosis and cell-cycle regulation. The 14-3-3 proteins are phospho-serine/phospho-threonine binding proteins that interact with a diverse array of binding partners. Because many 14-3-3 interactions are phosphorylation-dependent, 14-3-3 has been tightly integrated into the core phospho-regulatory pathways that are crucial for normal growth and development and that often become dysregulated in human disease states such as cancer. This review examines the recent advances that further elucidate the role of 14-3-3 proteins as integrators of diverse signaling cues that influence cell fate decisions and tumorigenesis.
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