[HTML][HTML] Cd19-dependent activation of Akt kinase in B-lymphocytes
DC Otero, SA Omori, RC Rickert - Journal of Biological Chemistry, 2001 - ASBMB
CD19 is rapidly phosphorylated upon B-cell antigen receptor (BCR) cross-linking, leading to
the recruitment of downstream signaling intermediates. A prominent feature of CD19
signaling is the binding and activation of phosphoinositide 3-kinase (P13K), which accounts
for the majority of PI3K activity induced by BCR ligation. Recent findings have implicated
activation of the serine/threonine kinase Akt as imparting survival signals in a PI3K-
dependent fashion. Using CD19-deficient B-lymphoma cells and mouse splenic B-cells, we …
the recruitment of downstream signaling intermediates. A prominent feature of CD19
signaling is the binding and activation of phosphoinositide 3-kinase (P13K), which accounts
for the majority of PI3K activity induced by BCR ligation. Recent findings have implicated
activation of the serine/threonine kinase Akt as imparting survival signals in a PI3K-
dependent fashion. Using CD19-deficient B-lymphoma cells and mouse splenic B-cells, we …