Various kinds of fatty acids are distributed in membrane phospholipids in mammalian cells
and tissues. The degree of fatty acid unsaturation in membrane phospholipids affects many
membrane-associated functions and can be influenced by diet and by altered activities of
lipid-metabolizing enzymes such as fatty acid desaturases. However, little is known about
how mammalian cells respond to changes in phospholipid fatty acid composition. In this
study we showed that stearoyl-CoA desaturase 1 (SCD1) knockdown increased the amount …