Enzymes required for de novo lipogenesis are induced in mammalian liver after a meal high
in carbohydrates. In addition to insulin, increased glucose metabolism initiates an
intracellular signaling pathway that transcriptionally regulates genes encoding lipogenic
enzymes. A cis-acting sequence, the carbohydrate response element (ChoRE), has been
found in the promoter region of several of these genes. ChREBP (carbohydrate response
element-binding protein) was recently identified as a candidate transcription factor in the …