Carnitine transport by organic cation transporters and systemic carnitine deficiency
K Lahjouji, GA Mitchell, IA Qureshi - Molecular genetics and metabolism, 2001 - Elsevier
The intracellular homeostasis is controlled by different membrane transporters. Organic
cation transporters function primarily in the elimination of cationic drugs, endogenous
amines, and other xenobiotics in tissues such as the kidney, intestine, and liver. Among
these molecules, carnitine is an endogenous amine which is an essential cofactor for
mitochondrial β-oxidation. Recently, a new family of transporters, named OCT (organic
cation transporters) has been described. In this minireview, we present the recent …
cation transporters function primarily in the elimination of cationic drugs, endogenous
amines, and other xenobiotics in tissues such as the kidney, intestine, and liver. Among
these molecules, carnitine is an endogenous amine which is an essential cofactor for
mitochondrial β-oxidation. Recently, a new family of transporters, named OCT (organic
cation transporters) has been described. In this minireview, we present the recent …