Prevalence of aberrant methylation of p14ARF over p16INK4a in some human primary tumors
G Dominguez, J Silva, JM Garcia, JM Silva… - Mutation Research …, 2003 - Elsevier
The INK4a/ARF locus encodes two unrelated tumor suppressor proteins, p16INK4a and
p14ARF, which participate in the two main cell-cycle control pathways, p16–Rb and p14–
p53. Methylation of CpG promoter islands has been described as a mechanism of gene
silencing. Exon 1 of the p16INK4a gene and the p14ARF promoter gene reside within CpG
islands. Therefore, both can become methylated de novo and silenced. It has recently been
proposed that the methylation changes in certain genes could be used as molecular …
p14ARF, which participate in the two main cell-cycle control pathways, p16–Rb and p14–
p53. Methylation of CpG promoter islands has been described as a mechanism of gene
silencing. Exon 1 of the p16INK4a gene and the p14ARF promoter gene reside within CpG
islands. Therefore, both can become methylated de novo and silenced. It has recently been
proposed that the methylation changes in certain genes could be used as molecular …