Methylglyoxal is an α-oxoaldehyde inevitably produced from triose-phosphate intermediates
of phosphorylating glycolysis, and also from amino acids and acetone. Recently, the
attention has been focused on the involvement of free radicals in methylglyoxal toxicity. In
this review, a summary of the relationship between methylglyoxal metabolism and free
radical production is presented, extending discussion from the possible metabolic routes to
the toxicological events by reviewing the role of free radicals in both generation and …