[HTML][HTML] Purification and identification of secreted oxidative stress-induced factors from vascular smooth muscle cells
Reactive oxygen species have been implicated in the pathogenesis of atherosclerosis and
hypertension, in part by promoting vascular smooth muscle cell (VSMC) growth. We have
previously shown that LY83583, a generator of O⨪ 2, activated extracellular signal-
regulated kinases (ERK1/2) with early (10 min) and late (2 h) peaks and stimulated VSMC
growth. To investigate whether secreted oxidative stress-induced factors (termed SOXF)
from VSMC were responsible for late ERK1/2 activation in response to LY83583, we purified …
hypertension, in part by promoting vascular smooth muscle cell (VSMC) growth. We have
previously shown that LY83583, a generator of O⨪ 2, activated extracellular signal-
regulated kinases (ERK1/2) with early (10 min) and late (2 h) peaks and stimulated VSMC
growth. To investigate whether secreted oxidative stress-induced factors (termed SOXF)
from VSMC were responsible for late ERK1/2 activation in response to LY83583, we purified …