In vitro selection of RNA molecules that bind specific ligands

AD Ellington, JW Szostak - nature, 1990 - nature.com
nature, 1990nature.com
Subpopulations of RNA molecules that bind specifically to a variety of organic dyes have
been isolated from a population of random sequence RNA molecules. Roughly one in 1010
random sequence RNA molecules folds in such a way as to create a specific binding site for
small ligands.
Abstract
Subpopulations of RNA molecules that bind specifically to a variety of organic dyes have been isolated from a population of random sequence RNA molecules. Roughly one in 1010 random sequence RNA molecules folds in such a way as to create a specific binding site for small ligands.
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