[HTML][HTML] Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors
A Beeser, ZM Jaffer, C Hofmann, J Chernoff - Journal of Biological …, 2005 - ASBMB
The canonical extracellular-regulated kinase (ERK) signaling cascade, consisting of the Ras-
Raf-Mek-ERK module, is critically important to many cellular functions. Although the general
mechanism of activation of the ERK cascade is well established, additional noncanonical
components greatly influence the activity of this pathway. Here, we focus on the group A p21-
activated kinases (Paks), which have previously been implicated in regulating both c-Raf
and Mek1 activity, by phosphorylating these proteins at Ser 338 and Ser 298, respectively. In …
Raf-Mek-ERK module, is critically important to many cellular functions. Although the general
mechanism of activation of the ERK cascade is well established, additional noncanonical
components greatly influence the activity of this pathway. Here, we focus on the group A p21-
activated kinases (Paks), which have previously been implicated in regulating both c-Raf
and Mek1 activity, by phosphorylating these proteins at Ser 338 and Ser 298, respectively. In …