Nef enhances human immunodeficiency virus type 1 infectivity and replication independently of viral coreceptor tropism
A Papkalla, J Münch, C Otto, F Kirchhoff - Journal of virology, 2002 - Am Soc Microbiol
A Papkalla, J Münch, C Otto, F Kirchhoff
Journal of virology, 2002•Am Soc MicrobiolWe investigated the infectivities and replicative capacities of a large panel of variants of the
molecular human immunodeficiency virus type 1 (HIV-1) NL4-3 clone that differ exclusively
in the V3 region of the viral envelope glycoprotein and the nef gene. Our results demonstrate
that Nef enhances virion infectivity and HIV-1 replication independently of the viral
coreceptor tropism.
molecular human immunodeficiency virus type 1 (HIV-1) NL4-3 clone that differ exclusively
in the V3 region of the viral envelope glycoprotein and the nef gene. Our results demonstrate
that Nef enhances virion infectivity and HIV-1 replication independently of the viral
coreceptor tropism.
Abstract
We investigated the infectivities and replicative capacities of a large panel of variants of the molecular human immunodeficiency virus type 1 (HIV-1) NL4-3 clone that differ exclusively in the V3 region of the viral envelope glycoprotein and the nef gene. Our results demonstrate that Nef enhances virion infectivity and HIV-1 replication independently of the viral coreceptor tropism.
American Society for Microbiology