Bax and Bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa
JA Rotolo, JG Maj, R Feldman, D Ren… - International Journal of …, 2008 - Elsevier
PURPOSE: To address in vivo the issue of whether Bax and Bak are functionally redundant
in signaling apoptosis, capable of substituting for each other. METHODS AND MATERIALS:
Mice were exposed to whole-body radiation, and endothelial cell apoptosis was quantified
using double immunostaining with TUNEL and anti-CD31 antibody. Crypt survival was
determined at 3.5 days after whole-body radiation by the microcolony survival assay.
Actuarial animal survival was calculated by the product-limit Kaplan-Meier method, and …
in signaling apoptosis, capable of substituting for each other. METHODS AND MATERIALS:
Mice were exposed to whole-body radiation, and endothelial cell apoptosis was quantified
using double immunostaining with TUNEL and anti-CD31 antibody. Crypt survival was
determined at 3.5 days after whole-body radiation by the microcolony survival assay.
Actuarial animal survival was calculated by the product-limit Kaplan-Meier method, and …