Timing of lethality from gastrointestinal syndrome in mice revisited
JA Rotolo, R Kolesnick, Z Fuks - International Journal of Radiation …, 2009 - redjournal.org
The standard time assay for mice lethality from the gastrointestinal (GI) vs. bone marrow
(BM) syndrome after whole body radiation (WBR) has recently been an issue of debate in
conjunction with studies that have provided a new mechanistic understanding of the
radiation-induced damage to the intestinal mucosa (1). Mice exposed to 8–20 Gy, single-
dose WBR succumb to depletion of the bone marrow stem cell/hematopoietic progenitor
pool (resulting in the BM syndrome)(2), the intestinal crypt stem cell clonogen compartment …
(BM) syndrome after whole body radiation (WBR) has recently been an issue of debate in
conjunction with studies that have provided a new mechanistic understanding of the
radiation-induced damage to the intestinal mucosa (1). Mice exposed to 8–20 Gy, single-
dose WBR succumb to depletion of the bone marrow stem cell/hematopoietic progenitor
pool (resulting in the BM syndrome)(2), the intestinal crypt stem cell clonogen compartment …