[HTML][HTML] The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates …
A Albor, S El-Hizawi, EJ Horn, M Laederich… - Journal of biological …, 2006 - ASBMB
Protein inhibitors of activated STATs (PIAS) family members are ubiquitin-protein isopeptide
ligase-small ubiquitin-like modifier ligases for diverse transcription factors. However, the
regulation of PIAS protein activity in cells is poorly understood. Previously, we reported that
expression of Trim32, a RING domain ubiquitin-protein isopeptide ligase-ubiquitin ligase
mutated in human limb-girdle muscular dystrophy type 2H (LGMD2H) and Bardet-Biedl
syndrome, is elevated during mouse skin carcinogenesis, protecting keratinocytes from …
ligase-small ubiquitin-like modifier ligases for diverse transcription factors. However, the
regulation of PIAS protein activity in cells is poorly understood. Previously, we reported that
expression of Trim32, a RING domain ubiquitin-protein isopeptide ligase-ubiquitin ligase
mutated in human limb-girdle muscular dystrophy type 2H (LGMD2H) and Bardet-Biedl
syndrome, is elevated during mouse skin carcinogenesis, protecting keratinocytes from …