The bone marrow vascular niche: home of HSC differentiation and mobilization

HG Kopp, ST Avecilla, AT Hooper, S Rafii - Physiology, 2005 - journals.physiology.org
HG Kopp, ST Avecilla, AT Hooper, S Rafii
Physiology, 2005journals.physiology.org
The bone marrow vasuclar niche consists of a network of thin-walled and fenestrated
sinusoidal vessels whose integrity is maintained and supported by surrounding
hematopoietic cells. However, this dependence is highly reciprocal in that the bone marrow
vasculature provides not only a conduit for mature hematopoietic cells to the peripheral
circulation but also a site where hematopoietic progenitors, especially megakaryocytes,
differentiate and set the stage for full reconstitution of hematopoiesis.
The bone marrow vasuclar niche consists of a network of thin-walled and fenestrated sinusoidal vessels whose integrity is maintained and supported by surrounding hematopoietic cells. However, this dependence is highly reciprocal in that the bone marrow vasculature provides not only a conduit for mature hematopoietic cells to the peripheral circulation but also a site where hematopoietic progenitors, especially megakaryocytes, differentiate and set the stage for full reconstitution of hematopoiesis.
American Physiological Society