[HTML][HTML] Haploinsufficient prostate tumor suppression by Nkx3. 1: a role for chromatin accessibility in dosage-sensitive gene regulation
AP Mogal, R Van Der Meer, PS Crooke… - Journal of Biological …, 2007 - ASBMB
Transcription factor haploinsufficiency plays a role in the pathogenesis of many diseases,
including cancer. In a mouse model of prostate tumor initiation, loss of a single allele of the
tumor suppressor Nkx3. 1 stochastically inactivates the expression of a class of dosage-
sensitive target genes. Here we show that dosage sensitivity is associated with the
differential histone H3/H4 acetylation states of Nkx3. 1 target genes. When histone
acetylation is induced in Nkx3. 1+/-mouse prostates with the histone deacetylase inhibitor …
including cancer. In a mouse model of prostate tumor initiation, loss of a single allele of the
tumor suppressor Nkx3. 1 stochastically inactivates the expression of a class of dosage-
sensitive target genes. Here we show that dosage sensitivity is associated with the
differential histone H3/H4 acetylation states of Nkx3. 1 target genes. When histone
acetylation is induced in Nkx3. 1+/-mouse prostates with the histone deacetylase inhibitor …