[HTML][HTML] Suppression of DNA repair by human T cell leukemia virus type 1 Tax is rescued by a functional p53 signaling pathway
SY Kao, FJ Lemoine, SJ Marriott - Journal of Biological Chemistry, 2000 - ASBMB
The Tax protein of human T cell leukemia virus type 1 is a viral transactivator and
transforming protein. Tax is known to suppress cellular nucleotide excision repair (NER),
and this activity has been proposed to play an important role in Tax transformation. In this
study we have investigated the mechanism by which Tax suppresses NER with specific
focus on the previously characterized ability of Tax to inhibit p53 function. Suppression of
NER by Tax was rescued by overexpression of wild-type p53; however, a p53 …
transforming protein. Tax is known to suppress cellular nucleotide excision repair (NER),
and this activity has been proposed to play an important role in Tax transformation. In this
study we have investigated the mechanism by which Tax suppresses NER with specific
focus on the previously characterized ability of Tax to inhibit p53 function. Suppression of
NER by Tax was rescued by overexpression of wild-type p53; however, a p53 …