Biochemical interaction between Tamm-Horsfall glycoprotein and Ig light chains in the pathogenesis of cast nephropathy.

ZQ Huang, PW Sanders - … ; a journal of technical methods and …, 1995 - europepmc.org
Laboratory investigation; a journal of technical methods and pathology, 1995europepmc.org
Background Cast nephropathy in multiple myeloma patients is caused by heterotypic
aggregation of Tamm-Horsfall glycoprotein (THP) with monoclonal light chains (Bence
Jones protein, BJP). Co-aggregation of these proteins is triggered by the binding of BJP to a
specific peptide portion of THP. Defining those factors that alter the interaction between BJP
and THP may help to understand further the pathogenesis of cast nephropathy and serve to
decrease the morbidity and mortality of cast nephropathy. We hypothesized that pH, calcium …
Background
Cast nephropathy in multiple myeloma patients is caused by heterotypic aggregation of Tamm-Horsfall glycoprotein (THP) with monoclonal light chains (Bence Jones protein, BJP). Co-aggregation of these proteins is triggered by the binding of BJP to a specific peptide portion of THP. Defining those factors that alter the interaction between BJP and THP may help to understand further the pathogenesis of cast nephropathy and serve to decrease the morbidity and mortality of cast nephropathy. We hypothesized that pH, calcium, furosemide, and the carbohydrate moiety of THP all modulate the protein-protein interaction between BJP and THP.
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