[HTML][HTML] Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 …
The complexity of canonical Wnt signaling comes not only from the numerous components
but also from multiple post-translational modifications. Protein phosphorylation is one of the
most common modifications that propagates signals from extracellular stimuli to downstream
effectors. To investigate the global phosphorylation regulation and uncover novel
phosphoproteins at the early stages of canonical Wnt signaling, HEK293 cells were
metabolically labeled with two stable isotopic forms of lysine and were stimulated for 0, 1, or …
but also from multiple post-translational modifications. Protein phosphorylation is one of the
most common modifications that propagates signals from extracellular stimuli to downstream
effectors. To investigate the global phosphorylation regulation and uncover novel
phosphoproteins at the early stages of canonical Wnt signaling, HEK293 cells were
metabolically labeled with two stable isotopic forms of lysine and were stimulated for 0, 1, or …