EBP50, a β-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma
T Shibata, M Chuma, A Kokubu, M Sakamoto… - Hepatology, 2003 - Elsevier
Wnt signaling mediated by β-catenin plays crucial roles in the development of hepatocellular
carcinoma and other cancers such as colorectal cancer. β-Catenin associates with T-cell
factor (TCF) transcription factors and functions as a transcriptional activator in the nucleus.
By protein interaction screening, we identified EBP50, a cytoplasmic protein with 2 PDZ
domains, as a β-catenin-associating molecule. EBP50 interacted with β-catenin through its
carboxyl-PDZ domain in vitro and in vivo. Northern blot and RT-PCR analysis revealed an …
carcinoma and other cancers such as colorectal cancer. β-Catenin associates with T-cell
factor (TCF) transcription factors and functions as a transcriptional activator in the nucleus.
By protein interaction screening, we identified EBP50, a cytoplasmic protein with 2 PDZ
domains, as a β-catenin-associating molecule. EBP50 interacted with β-catenin through its
carboxyl-PDZ domain in vitro and in vivo. Northern blot and RT-PCR analysis revealed an …