The clinical and pathologic findings in two white male children with repeated infections,
including lymphadenitis, aphthous stomatitis, enteritis, pneumonitis, osteomyelities, etc. are
described. Tissue removed at laparotomy in one patient, and at necropsy in the other,
showed infiltration of organs by lipid histiocytes containing yellow-brown pigment. Although
the histochemical properties of the cells show similarities to the lipid histiocytes of Niemann-
Pick disease, the condition described is considered to differ from other forms of lipid …