[HTML][HTML] The carboxyl terminus of GLUT4 contains a serine-leucine-leucine sequence that functions as a potent internalization motif in Chinese hamster ovary cells
RJ Garippa, A Johnson, J Park, RL Petrush… - Journal of Biological …, 1996 - ASBMB
To characterize the trafficking motifs contained in the carboxyl terminus of GLUT4, a chimera
(GTCTR) was constructed in which the carboxyl-terminal 30 amino acids of GLUT4 were
substituted for the amino-terminal cytoplasmic domain of the transferrin receptor (TR). The
endocytic behavior of this chimera was characterized in Chinese hamster ovary cells. The
GTCTR chimera had a more predominant intracellular distribution compared to the TR. Only
20% of the GTCTR chimera is on the surface at steady-state compared to 35% of the TR …
(GTCTR) was constructed in which the carboxyl-terminal 30 amino acids of GLUT4 were
substituted for the amino-terminal cytoplasmic domain of the transferrin receptor (TR). The
endocytic behavior of this chimera was characterized in Chinese hamster ovary cells. The
GTCTR chimera had a more predominant intracellular distribution compared to the TR. Only
20% of the GTCTR chimera is on the surface at steady-state compared to 35% of the TR …