Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
P Gual, Y Le Marchand-Brustel, JF Tanti - Biochimie, 2005 - Elsevier
This review will provide insight on the current understanding of the regulation of insulin
signaling in both physiological and pathological conditions through modulations that occur
with regards to the functions of the insulin receptor substrate 1 (IRS1). While the
phosphorylation of IRS1 on tyrosine residue is required for insulin-stimulated responses, the
phosphorylation of IRS1 on serine residues has a dual role, either to enhance or to
terminate the insulin effects. The activation of PKB in response to insulin propagates insulin …
signaling in both physiological and pathological conditions through modulations that occur
with regards to the functions of the insulin receptor substrate 1 (IRS1). While the
phosphorylation of IRS1 on tyrosine residue is required for insulin-stimulated responses, the
phosphorylation of IRS1 on serine residues has a dual role, either to enhance or to
terminate the insulin effects. The activation of PKB in response to insulin propagates insulin …