Growing evidence reveals that insulin signal pathway is not static, but is rather a dynamic,
flexible, and fed in by negative (Yin) and positive (Yang) regulation in response to
environmental changes. Normal insulin response reflects the balance between Yin and
Yang regulation acting upon insulin signaling pathway. Conceivably, imbalance between
the Yin and Yang results in abnormal insulin sensitivity such as insulin resistance. IRS‐
proteins are insulin receptor substrates that mediate insulin signaling via multiple tyrosyl …