Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on …
RA Sperling, PS Aisen, LA Beckett, DA Bennett… - Alzheimer's & …, 2011 - Elsevier
The pathophysiological process of Alzheimer's disease (AD) is thought to begin many years
before the diagnosis of AD dementia. This long “preclinical” phase of AD would provide a
critical opportunity for therapeutic intervention; however, we need to further elucidate the link
between the pathological cascade of AD and the emergence of clinical symptoms. The
National Institute on Aging and the Alzheimer's Association convened an international
workgroup to review the biomarker, epidemiological, and neuropsychological evidence, and …
before the diagnosis of AD dementia. This long “preclinical” phase of AD would provide a
critical opportunity for therapeutic intervention; however, we need to further elucidate the link
between the pathological cascade of AD and the emergence of clinical symptoms. The
National Institute on Aging and the Alzheimer's Association convened an international
workgroup to review the biomarker, epidemiological, and neuropsychological evidence, and …