[HTML][HTML] Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin
Insulin-like growth factor-1 (IGF-1) and insulin are known to prevent apoptosis. The signaling
network of IGF-1 and insulin occurs via multiple pathways involving different insulin receptor
substrates (IRSs). To define their roles in the anti-apoptotic function of IGF-1 and insulin, we
established brown pre-adipocyte cell lines from wild-type and IRS knockout (KO) animals. In
response to 16 h of serum deprivation, IRS-1-deficient cells showed a significant decrease
in response to IGF-1 protection from apoptosis, whereas no changes were observed in the …
network of IGF-1 and insulin occurs via multiple pathways involving different insulin receptor
substrates (IRSs). To define their roles in the anti-apoptotic function of IGF-1 and insulin, we
established brown pre-adipocyte cell lines from wild-type and IRS knockout (KO) animals. In
response to 16 h of serum deprivation, IRS-1-deficient cells showed a significant decrease
in response to IGF-1 protection from apoptosis, whereas no changes were observed in the …