[HTML][HTML] ERK1/2 activation mediates Aβ oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures
YH Chong, YJ Shin, EO Lee, R Kayed… - Journal of biological …, 2006 - ASBMB
In this study, we investigated the molecular basis for the altered signal transduction
associated with soluble amyloid β-protein (Aβ) oligomer-mediated neurotoxicity in the
hippocampus, which is primarily linked to cognitive dysfunction in Alzheimer disease (AD).
As measured by media lactate dehydrogenase levels, and staining with propidium iodide,
acute exposure to low micromolar concentrations of the Aβ1-42 oligomer significantly
induced cell death. This was accompanied by activation of the ERK1/2 signal transduction …
associated with soluble amyloid β-protein (Aβ) oligomer-mediated neurotoxicity in the
hippocampus, which is primarily linked to cognitive dysfunction in Alzheimer disease (AD).
As measured by media lactate dehydrogenase levels, and staining with propidium iodide,
acute exposure to low micromolar concentrations of the Aβ1-42 oligomer significantly
induced cell death. This was accompanied by activation of the ERK1/2 signal transduction …