Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes
LD Baker, DJ Cross, S Minoshima… - Archives of …, 2011 - jamanetwork.com
Background: Insulin resistance is a causal factor in prediabetes (PD) and type 2 diabetes
(T2D) and increases the risk of developing Alzheimer disease (AD). Reductions in cerebral
glucose metabolic rate (CMRglu) as measured by fludeoxyglucose F 18–positron emission
tomography (FDGPET) in parietotemporal, frontal, and cingulate cortices are associated with
increased AD risk and can be observed years before dementia onset. Objectives:
Toexaminewhethergreaterhomeostasismodel assessment insulin resistance (HOMA-IR) is …
(T2D) and increases the risk of developing Alzheimer disease (AD). Reductions in cerebral
glucose metabolic rate (CMRglu) as measured by fludeoxyglucose F 18–positron emission
tomography (FDGPET) in parietotemporal, frontal, and cingulate cortices are associated with
increased AD risk and can be observed years before dementia onset. Objectives:
Toexaminewhethergreaterhomeostasismodel assessment insulin resistance (HOMA-IR) is …