[PDF][PDF] Ciliary trafficking: CEP290 guards a gated community
E Betleja, DG Cole - Current biology, 2010 - cell.com
E Betleja, DG Cole
Current biology, 2010•cell.comCiliary Trafficking: CEP290 Guards a Gated Community Page 1 in the regulation of sexual
maturity in male morphs was not entirely predictable, yet with some imagination such a role can
be reconciled with Mc4r’s known functions and is thus intriguing enough to stimulate further
investigation [14]. For one, Mc4r acts in the hypothalamus, thus making a link to the hormonal
hypothalamus–pituitary–gonad (HPG) axis that triggers sexual maturity in vertebrates at least
plausible. In fact, in female rats Mc4r activity can affect expression of certain hormones of the …
maturity in male morphs was not entirely predictable, yet with some imagination such a role can
be reconciled with Mc4r’s known functions and is thus intriguing enough to stimulate further
investigation [14]. For one, Mc4r acts in the hypothalamus, thus making a link to the hormonal
hypothalamus–pituitary–gonad (HPG) axis that triggers sexual maturity in vertebrates at least
plausible. In fact, in female rats Mc4r activity can affect expression of certain hormones of the …
Summary
A recent study reveals that the large coiled-coil protein CEP290 is an integral component of the transition zone between the cell body and the cilium and functions as a gatekeeper to regulate trafficking of ciliary proteins.
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