[HTML][HTML] ASIC2b-dependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1
ASIC3, an acid-sensing ion channel subunit expressed essentially in sensory neurons, has
been proposed to be involved in pain. We show here for the first time that native ASIC3-like
currents were increased in cultured dorsal root ganglion (DRG) neurons following protein
kinase C (PKC) stimulation. This increase was induced by the phorbol ester PDBu and by
pain mediators, such as serotonin, which are known to activate the PKC pathway through
their binding to G protein-coupled receptors. We demonstrate that this regulation involves …
been proposed to be involved in pain. We show here for the first time that native ASIC3-like
currents were increased in cultured dorsal root ganglion (DRG) neurons following protein
kinase C (PKC) stimulation. This increase was induced by the phorbol ester PDBu and by
pain mediators, such as serotonin, which are known to activate the PKC pathway through
their binding to G protein-coupled receptors. We demonstrate that this regulation involves …