Background Voltage-gated sodium channels (Nav) mediate neuronal action potentials.
Tetrodotoxin inhibits all Nav isoforms, but Nav1. 8 and Nav1. 9 are relatively tetrodotoxin-
resistant (TTX-r) compared to other isoforms. Nav1. 8 is highly expressed in dorsal root
ganglion neurons and is functionally linked to nociception, but the sensitivity of TTX-r
isoforms to inhaled anesthetics is unclear. Methods The sensitivities of heterologously
expressed rat TTX-r Nav1. 8 and endogenous tetrodotoxin-sensitive (TTX-s) Nav to the …