[HTML][HTML] Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver
Lipid homeostasis is transcriptionally regulated by three DNA-binding proteins, designated
sterol regulatory element-binding protein (SREBP)-1a,-1c, and-2. Oligonucleotide arrays
hybridized with RNA made from livers of transgenic SREBP-1a, transgenic SREBP-2, and
SREBP cleavage-activating protein knockout mice recently identified 33 genes regulated by
SREBPs in liver, four of which had no known connection to lipid metabolism. One of the four
genes was PCSK9, which encodes proprotein convertase subtilisin/kexin type 9a, a protein …
sterol regulatory element-binding protein (SREBP)-1a,-1c, and-2. Oligonucleotide arrays
hybridized with RNA made from livers of transgenic SREBP-1a, transgenic SREBP-2, and
SREBP cleavage-activating protein knockout mice recently identified 33 genes regulated by
SREBPs in liver, four of which had no known connection to lipid metabolism. One of the four
genes was PCSK9, which encodes proprotein convertase subtilisin/kexin type 9a, a protein …