Tumor–microenvironment interactions: Dangerous liaisons

IP Witz - Advances in cancer research, 2008 - Elsevier
The interaction between microenvironmental components and tumor cells is bidirectional.
Tumor cells and their products are capable of regulating and altering gene expression in
nontumor cells residing in or infiltrating into the microenvironment and exert selective
pressures on such cells, thereby shaping their phenotype. Conversely, microenvironmental
components regulate gene expression in tumor cells thereby directing the tumor into one or
several possible molecular evolution pathways, some of which may lead to metastasis. This …