Intracellular versican expression in mesenchymal spindle cell tumors contrasts with extracellular expression in epithelial and other tumors—a tissue microarray-based …

A Bhardwaj, WL Frankel, NS Pellegata… - Applied …, 2008 - journals.lww.com
Versican is a large chondroitin sulfate proteoglycan that is an integral component of the
extracellular matrix protein. It regulates cell proliferation, adhesion, and migration, and is
expressed in a variety of normal tissues and tumors. We studied the pattern of versican
expression in various epithelial, mesenchymal, neural, and hematopoietic tumors using
immunohistochemistry on tissue microarrays. The primary antibody used was mouse
monoclonal antibody to versican (clone 8S270, 1: 4000, US Biological). Sections from 3 …