Tyrosine-phosphorylated bacterial effector proteins: the enemies within

S Backert, M Selbach - Trends in microbiology, 2005 - cell.com
S Backert, M Selbach
Trends in microbiology, 2005cell.com
The tyrosine phosphorylation of proteins has a central role during signal transduction in
eukaryotes. Recent progress shows that tyrosine phosphorylation is also a common feature
of several effector proteins translocated by bacterial type III and type IV secretion systems.
The involvement of these secretion systems in disease development is exemplified by a
variety of pathogenic processes: pedestal formation (Tir of EPEC and Citrobacter), cell
scattering (CagA of Helicobacter), invasion (Tarp of Chlamydia) and possibly …
The tyrosine phosphorylation of proteins has a central role during signal transduction in eukaryotes. Recent progress shows that tyrosine phosphorylation is also a common feature of several effector proteins translocated by bacterial type III and type IV secretion systems. The involvement of these secretion systems in disease development is exemplified by a variety of pathogenic processes: pedestal formation (Tir of EPEC and Citrobacter), cell scattering (CagA of Helicobacter), invasion (Tarp of Chlamydia) and possibly proinflammatory responses and cell proliferation (BepD–F of Bartonella). The discovery that different bacterial pathogens use this common strategy to subvert host-cell function suggests that more examples will soon emerge.
cell.com