Intracerebral dendritic cells (DC) have recently been identified in neuroinflammation initiated
peripherally by brain-targeted autoimmunity or infection. The present study detects DC in
photochemically induced cortical ischemia of the mouse brain, a brain-intrinsic lesion model
characterized by the lack of an overt T cell response. Concomitant to leukocyte infiltration of
the infarcted area, cells expressing the pan-DC surface marker CD11c appeared at the
lesion and persisted for weeks. These DC were located at the border zone of the infarct and …