Optic nerve head extracellular matrix in primary optic atrophy and experimental glaucoma

JC Morrison, ME Dorman-Pease… - Archives of …, 1990 - jamanetwork.com
• Unilateral glaucomatous optic neuropathy and optic nerve transections were produced in
cynomolgous monkeys, and the optic nerve heads were examined by light and electron
microscopic immunohistochemistry. Glaucomatous nerve heads showed increased labeling
for collagen type IV along the margins of beams in the lamina cribrosa, due to accumulation
of basement membrane-like materials. We also noted material in the pores of the laminar
beams that labeled with antibodies to collagen types I, III and IV, but not elastin. In …