Actin'up: RhoB in cancer and apoptosis
GC Prendergast - Nature Reviews Cancer, 2001 - nature.com
Nature Reviews Cancer, 2001•nature.com
RhoB is a small GTPase that regulates actin organization and vesicle transport. It is required
for signalling apoptosis in transformed cells that are exposed to farnesyltransferase
inhibitors, DNA-damaging agents or taxol. Genetic analysis in mice indicates that RhoB is
dispensable for normal cell physiology, but that it has a suppressor or negative modifier
function in stress-associated processes, including cancer.
for signalling apoptosis in transformed cells that are exposed to farnesyltransferase
inhibitors, DNA-damaging agents or taxol. Genetic analysis in mice indicates that RhoB is
dispensable for normal cell physiology, but that it has a suppressor or negative modifier
function in stress-associated processes, including cancer.
Abstract
RhoB is a small GTPase that regulates actin organization and vesicle transport. It is required for signalling apoptosis in transformed cells that are exposed to farnesyltransferase inhibitors, DNA-damaging agents or taxol. Genetic analysis in mice indicates that RhoB is dispensable for normal cell physiology, but that it has a suppressor or negative modifier function in stress-associated processes, including cancer.
nature.com