[HTML][HTML] Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF
V Perrot, J Vazquez-Prado, JS Gutkind - Journal of Biological Chemistry, 2002 - ASBMB
Plexins represent a novel family of transmembrane receptors that transduce attractive and
repulsive signals mediated by the axon-guiding molecules semaphorins. Emerging
evidence implicates Rho GTPases in these biological events. However, Plexins lack any
known catalytic activity in their conserved cytoplasmic tails, and how they transduce signals
from semaphorins to Rho is still unknown. Here we show that Plexin B2 associates directly
with two members of a recently identified family of Dbl homology/pleckstrin homology …
repulsive signals mediated by the axon-guiding molecules semaphorins. Emerging
evidence implicates Rho GTPases in these biological events. However, Plexins lack any
known catalytic activity in their conserved cytoplasmic tails, and how they transduce signals
from semaphorins to Rho is still unknown. Here we show that Plexin B2 associates directly
with two members of a recently identified family of Dbl homology/pleckstrin homology …