Studies on the preservation of human blood. II. The relationship of erythrocyte adenosine triphosphate levels and other in vitro measures to red cell storageability

RJ Dern, GJ Brewer… - The Journal of laboratory …, 1967 - translationalres.com
In a study involving 37 subjects, whole blood was stored at 4° C. for 21 and 28 days in either
ACD or CPD anticoagulant, following which, the in vivo viability of the stored red cells was
measured. There was a high degree of correlation (R= 0.95) between the postinfusion
viability of stored cells and poststorage adenosine triphosphate (ATP) levels. This indicates
the potential use of ATP determinations to predict in vivo red cell viability after in vitro
storage. In contract, the correlation between prestorage ATP levels and poststorage RBC …